Arailym Aronova

Keywords HDAC9 inflammasome atherosclerosis inflammation NLRP3 cis-regulatory element stroke GWAS nanobiologics therapeutics Introduction Atherosclerotic cardiovascular disease (CVD), including stroke and myocardial infarction, is the leading cause of death and disability worldwide.1 Chronic inflammation is a key driver of atheroprogression, whereas resolution of inflammation attenuates disease progression.2,3 Therefore, extensive efforts are being made to target inflammation in...

1. Introduction Atherosclerosis, a chronic inflammatory disease of the arterial wall, is the primary pathology underlying cardiovascular disease (CVD), including stroke and myocardial infarction, which are major causes of disability and mortality in industrialized countries [1]. The initiation and progression of atherosclerosis involve a complex interplay of various cell types and signaling pathways, leading to plaque formation and subsequent narrowing of the arteries [2,3,4].