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Rapid Carrier-Free Self-Assembled Aqueous Nanoformulations of Ten BCS Class II Drugs, Propofol, and Hydroxyapatite Using FAST Nanoplatform

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By Stephen Hsu, Amani Mouna, Archith Philip
| preprints.org
You are already at the latest version Poor aqueous solubility remains a major barrier to the development, repurposing, and improved delivery of many clinically important small-molecule drugs. This problem is especially important for Biopharmaceutics Classification System (BCS) Class II drugs, in which intestinal permeability may be acceptable but dissolution and aqueous formulation compatibility limit absorption, formulation flexibility, and translational testing.
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