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Integrated workflow for analysis of immune enriched spatial proteomic data with IMmuneCite - Scientific Reports
Abstract Spatial proteomics enable detailed analysis of tissue at single cell resolution. However, creating reliable segmentation masks and assigning accurate cell phenotypes to discrete cellular phenotypes can be challenging. We introduce IMmuneCite, a computational framework for comprehensive image pre-processing and single-cell dataset creation, focused on defining complex immune landscapes when using spatial proteomics platforms.
Spatially resolved immune exhaustion within the alloreactive microenvironment predicts liver transplant rejection
Research Article IMMUNOLOGY Arianna Barbetta https://orcid.org/0000-0001-7062-3236, Brittany Rocque, [...] , Sarah Bangerth https://orcid.org/0000-0002-7952-0679, Kelly Street https://orcid.org/0000-0001-6379-5013, [...] , Carly Weaver, Shefali Chopra, Janet Kim, Linda Sher, Brice Gaudilliere https://orcid.org/0000-0002-3475-5706, [...] , Omid Akbari https://orcid.org/0000-0002-4359-9725, Rohit Kohli https://orcid.org/0000-0002-0198-7703, and Juliet Emamaullee...
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