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Arijit Ghosh

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Johannesburg, Mumbai
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Managing Editor @BloombergAfrica via @BloombergAsia. Usual disclaimers. Sign up for Africa Newsletter: www.bloomberg.com/account/newsletters/next-africa

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Articles

HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination

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By Wenjing Li, Bo Wu, Boya Gao, Elizabeth Irvin, Arijit Ghosh Verified, Lillian Eliaz, Yuxin Huang, YoungHo Kwon, Clara M. Stiefel, David Zhao, Humberto Suárez, Salvador Alejo, O’Taveon Fitzgerald, Xuemei Song, Sandip Kumar Rath, Elizabeth V. Wasmuth, David Yu, Siyuan Zheng, Justin Leung, Xiaoyu Xue, Hong Wang, Jae-Hoon Ji, Weixing Zhao, Tengyang Ni
| Nature Verified
Abstract R-loops are transcription-induced, three-stranded nucleic acid structures that, if not properly resolved, can disrupt DNA repair and compromise genome stability. BRCA2, a tumor suppressor vital for homologous recombination (HR), also contributes to R-loop regulation, though the underlying mechanisms remain poorly understood. Here, we identify HELZ as a direct BRCA2 interactor and characterize it as an ssRNA-specific R-loop resolvase.
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ABL kinase inactivation induces transcription-replication conflicts and impairs replication fork progression in metastatic small cell lung cancer

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By Jing Gu, Kevin Scott, Arijit Ghosh Verified, Douglas C. Rouse, Jacob P. Hoj, Fengqi Zhang, Boya Gao, Margaret W. Barbier, Lee Zou, Ann Marie Pendergast, Roberto H. Barbier, Michael W. Caminear
| Cell Reports Verified
ArticleVolume 45, Issue 7117699Open access Affiliations & Notes 1Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, United States of America 2Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, United States of America 3Division of Laboratory Animal Resources, Duke University School of Medicine, Durham, NC, United States of America Article Info Publication History: Received June 2, 2025; Revised May 6,...
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Precious metals case involving Kadwa and Khan postponed.

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By Arijit Ghosh Verified, Terri-Ann Brouwers. South..
| Fullview SA
By Lehlohonolo Lehana. The case against Gauteng Hawks head Major General Ebrahim Kadwa, crime intelligence deputy head Feroz Khan, and businessman Tariq Downes returned to the Kempton Park Magistrate’s Court this morning. The trio faces charges related to the unlawful possession and dealing in precious metals. The accused are out on R20,000 bail each following their arrest in May. During court proceedings on Tuesday, it emerged that a warrant of arrest has been issued for Khan.
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