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Arjun Bharioke on Muck Rack

Arjun Bharioke

As seen in: Cell Press
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Articles

Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex

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By Martin Munz, Arjun Bharioke, Georg Kosche, Verónica Moreno-Juan
| Cell Press Verified
Quantification and statistical analysis Filtering of calcium traces On the galvo-galvo scanning microscope, two-photon recordings were imported as 3D matrices of recorded activity within a spatial field of view over time. Similarly, recordings taken with high -speed arbitrary frame scan mode on the acousto-optic two-photon microscope were also imported as 3D matrices across time, by taking the mean projection across all imaging planes, at each time point.
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General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons

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By Byrnes E.J, Arjun Bharioke, Martin Munz, Alexandra Brignall
| Cell Press Verified
Highlights • Activity of layer 5 PNs synchronizes globally in different anesthetics • Other mouse cortical cell types show no consistent increase in synchrony • Changes in layer 5 synchrony coincide with the loss and recovery of consciousness • Basal, but not apical, layer 5 dendrites are in synchrony with somas Summary General anesthetics induce loss of consciousness, a global change in behavior.
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