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Arpana Agrawal

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Articles

The Psychiatric Genomics Consortium: Discoveries and Directions

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By Arpana Agrawal
| Texas Medical Center
Publication Date 8-1-2025 Journal The Lancet Psychiatry DOI 10.1016/S2215-0366(25)00124-5 PubMedCentral® Posted Date 6-26-2026 PubMedCentral® Full Text Version Author MSS Abstract The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions.
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Cornichon Homolog-3 (Cnih3) deletion impairs spatial memory, operant learning, and fentanyl self-administration behavior

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By Tania Lintz, Alex Liu, Ashley Park, Joanna J. Dearman, Arpana Agrawal, Elliot Nelson, Jose Morón, Talal A. Aal
| Nature Verified
Abstract Opioid misuse remains rampant as new synthetic opioids reach the market. Large-scale genetic tools like the GWAS identify previously unrecognized targets and biomarkers in opioid misuse with the hopes of combating the opioid epidemic.
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Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents

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By Heather Leduc-Pessah, Brendan McAllister, Sarthak Sinha, Sierra Stokes-Heck, Daisuke Nishizawa, Churmy Y. Fan, Marie-Kim St-Pierre, Amyaouch Bradaia, Manon Defaye, Nicole E Burma, Jonathan Damblon, Einer Muñoz-Pino, Frank Visser, Marie-France Dorion, Luke Healy, Júlia Canet-Pons, Zizhen Zhang, Flávia Antunes, Valerio E.C. Piscopo, Margaret Medina, Ken-ichi Fukuda, Tatsuya Ichinohe, Masakazu Hayashida, Emma Johnson, Arpana Agrawal, Louisa Degenhardt, Nicholas Martin, Gerald W. Zamponi, Elliot Nelson, Christophe Altier, Marie-Eve Tremblay, Chad A Bousman, Stefano Stifani, Yves De Koninck, Kazutaka Ikeda, Jeff Biernaskie, Tuan Trang, Makoto Nagashima
| Cell Press Verified
Keywords opioid analgesia opioid withdrawal microglia transcriptomics transcription factor genetics personalized medicine Get full text access Log in, subscribe or purchase for full access. References 1. Montgomery, L.S. Pain management with opioids in adults J. Neurosci. Res. 2022; 100:10-18 2. Kalso, E. ∙ Edwards, J.E. ∙ Moore, A.R. ... Opioids in chronic non-cancer pain: systematic review of efficacy and safety Pain. 2004; 112:372-380 3. Bakare, T.T. ∙ Uzoeto, H.O. ∙ Gonlepa, L.N. ...
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