The most expensive U.S. cities are costly for a good reason – several, really. Residents are willing to pay extra for everything from housing to food to gas if it allows them to live someplace with great weather. Others are looking for cosmopolitan living, with a host of restaurants, museums and other cultural options on tap. However, in some cases, simple isolation plays a leading role. When pretty much everything has to be imported over long supply lines, prices are bound to be higher.