Ashique Rafique on Muck Rack

Ashique Rafique

As seen in: Nature, Cell Host & Microbe
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Articles

Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes - Nature Communications

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By Yi Zhou, Ashique Rafique
| Nature Verified
Abstract Oncostatin M (OSM) is a unique Interleukin 6 (IL-6) family cytokine that plays pivotal roles in numerous biological events by signaling via two types of receptor complexes. While type I OSM receptor complex is formed by glycoprotein 130 (gp130) heterodimerization with Leukemia Inhibitory Factor receptor (LIFR), type II OSM receptor complex is composed of gp130 and OSM receptor (OSMR).
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Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM - Nature Communications

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By Kei Saotome, Ashique Rafique, Andrew Murphy, Drew Dudgeon
| Nature Verified
Abstract The recognition of antigenic peptide-MHC (pMHC) molecules by T-cell receptors (TCR) initiates the T-cell mediated immune response. Structural characterization is key for understanding the specificity of TCR-pMHC interactions and informing the development of therapeutics. Despite the rapid rise of single particle cryoelectron microscopy (cryoEM), x-ray crystallography has remained the preferred method for structure determination of TCR-pMHC complexes.
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Structure of the Inmazeb cocktail and resistance to Ebola virus escape

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By Benjamin Fulton, Vamseedhar Rayaprolu, Ashique Rafique
| Cell Host & Microbe Verified
Antibodies REGN3471 Regeneron N/A REGN3479 Regeneron N/A REGN3470 Regeneron N/A mAb114 Misasi et al. 26 Misasi J. Gilman M.S.A. Kanekiyo M. Gui M. Cagigi A. Mulangu S. Corti D. Ledgerwood J.E. Lanzavecchia A. Cunningham J. et al. Structural and molecular basis for Ebola virus neutralization by protective human antibodies.
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