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Ashley D. Nemes-Baran on Muck Rack

Ashley D. Nemes-Baran

As seen in: Cell Reports
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Articles

Fractalkine-Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination

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By Donovan White, Tara DeSilva, Ashley D. Nemes-Baran
| Cell Reports Verified
Highlights • Ameboid microglia invade the corpus callosum and engulf OPCs during development • Majority of OPCs engulfed by ameboid microglia in the corpus callosum are viable • Fractalkine receptor-deficient microglia exhibit a reduction in engulfment of OPCs • Fractalkinereceptor-deficient mice have reduced myelin thickness in adulthood Summary Oligodendrogenesis occurs during early postnatal development, coincident with neurogenesis and synaptogenesis, raising the possibility that...
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