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Ashwat Nagarajan on Muck Rack

Ashwat Nagarajan

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Articles

TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors

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By Shelley M. Herbrich, Mehdi Chaib, Swetha Anandhan, Ashwat Nagarajan, Baoxiang Guan, Nishant Gandhi, Jared Gilliam, Milan Radovich, Padmanee Sharma, Samuel W. Andrewes
| Cell Press Verified
Keywords tumor immunology immune checkpoint therapy clonal hematopoiesis TET2 antigen presentation cross-priming Introduction Clonal hematopoiesis (CH) is an age-related phenomenon characterized by overrepresentation of mature blood cells arising from a single clone (variant allele frequency >2%) and can be detected in over 10% of healthy adults.1 CH is caused by the acquisition of non-oncogenic mutations in early hematopoietic stem or progenitor cells that provide a selective advantage over...
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