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Ashwin Narain

As seen in: Nature, Cell Press
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Articles by Ashwin Narain

Correction: USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer - Oncogene

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By Michaela Reissland, Saskia Tauch, Jeroen M. Bugter, Clemens Schulte, Daniel Solvie, Ashwin Narain, Anne-Claire Jacomin, Carsten P. Ade, Viktoria Buck, Vivian Li, Armin Wiegering, Martin Eilers, Hans Michael Maric, Mathias Rosenfeldt, Madelon M. Maurice, Ivan Dikic, Amir Orian
| Nature Verified
The affiliation of the author Gerti Beliu has been corrected from “Institute of Lung Health and Immunity, Helmholtz Center, Munich, Germany” to “Rudolf-Virchow-Center for Integrative and Translational Imaging, University of Wuerzburg, Wuerzburg, Germany.” The original article has been corrected.
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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

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By Ashwin Narain, Am Hubland, Pranjali Bhandare, Bikash Adhikari
| Cell Press Verified
Highlights • Auxin-inducible degradation discriminates direct roles of human SPT6 in transcription • Acute loss of SPT6 globally impairs RNAPII processivity and speed • SPT6 is required for efficient transcription termination on protein-coding genes • Long-term loss of SPT6 ultimately results in cryptic intragenic transcription Summary SPT6 is a histone chaperone that tightly binds RNA polymerase II (RNAPII) during transcription elongation. However, its primary role in transcription is uncertain.
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