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Asra Almubarak on Muck Rack

Asra Almubarak

As seen in: BioRxiv, The Journal of Biological Chemistry
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Articles

Foxc1 and Foxc2 function in osteochondral progenitors for the progression through chondrocyte hypertrophy and mineralization of the primary ossification center.

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By Asra Almubarak, Qiuwan Zhang, Cheng-Hai Zhang, Tsutomu Kume
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.04.26.538325 Abstract The forkhead box transcription factor genes Foxc1 and Foxc2 are expressed in the condensing mesenchyme of the developing skeleton prior to the onset of chondrocyte differentiation. To determine the roles of these transcription factors in limb development we deleted both Foxc1 and Foxc2 in lateral plate mesoderm using the Prx1-cre mouse line.
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Loss of Foxc1 and Foxc2 function in chondroprogenitor cells disrupts endochondral ossification

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By Edmonton AB, Asra Almubarak, Edmonton AB Canada, Rotem Lavy
| The Journal of Biological Chemistry Verified
Abstract Endochondral ossification initiates the growth of the majority of the mammalian skeleton and is tightly controlled through gene regulatory networks. The forkhead box transcription factors Foxc1 and Foxc2 have been demonstrated to regulate aspects of osteoblast function in the formation of the skeleton but their roles in chondrocytes to control endochondral ossification are less clear.
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