Atsu Aiba

Abstract The release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm, followed by its reuptake by sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), is critical for the muscle contraction-relaxation cycle. In this study, we identify a small transmembrane protein, predominantly expressed in fast-twitch muscles, which regulates SERCA1 activity.

Keywords fragile X syndrome mutant marmoset neurodevelopmental disorders non-human primate model Research topic(s) CP: Neuroscience Introduction Fragile X syndrome (FXS) is a monogenic cause of intellectual disability, developmental delay, and autism spectrum disorder (ASD), estimated to occur in 1 in 5,000 males and 1 in 4,000 to 1 in 8,000 females.1,2,3 It is caused by a CGG trinucleotide repeat expansion in the 5′ untranslated region of the fragile X messenger ribonucleoprotein 1 (FMR1)...

Abstract D-site binding protein, DBP, is a clock-controlled transcription factor and drives daily rhythms of physiological processes through the regulation of an array of genes harboring a DNA binding motif, D-box. DBP protein levels show a circadian oscillation with an extremely robust peak/trough ratio, but it is elusive how the temporal pattern is regulated by post-translational regulation. In this study, we show that DBP protein levels are down-regulated by the ubiquitin-proteasome pathway.