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Audre P. May on Muck Rack

Audre P. May

As seen in: Cell Press
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Articles

Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function

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By Oliver Takacsi-Nagy, Sivakanthan Kasinathan, Austin Hartman, Yajie Yin, Lujing Wu, Andy Chen, Laura Moser, Audre P. May, Gabriella C. Reeder, Emily Fuentes, Courtney Kernick, Johnathan Lu, Alison McClellan, Colin J. Raposo, Patrick K. Yan, Peng Xu, Elena Sotillo, Justin Eyquem, Crystal L. Mackall, Theodore L. Roth, Ansuman T. Satpathy, Brendan Terrall, Nicole E. Theberath
| Cell Press Verified
Keywords genome engineering synthetic biology transcriptional regulation CAR T cells Introduction Human protein-coding genes arose primarily through the repurposing of domains from ancestral genes via addition, deletion, or shuffling, rather than through de novo sequence creation.1,2,3,4,5,6,7 This principle inspired early protein engineering efforts, where domain shuffling was used to recombine genes, first randomly and later at pre-defined crossover points for various applications,...
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