Aviva Geretz on Muck Rack

Aviva Geretz

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Articles

Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts - Nature Communications

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By Philip K. Ehrenberg, Aviva Geretz, Meta Volcic, Adam T. Waickman, Dominic Paquin-Proulx, Matthew Creegan, Akshara Narahari, Jeffrey R Currier, Carlo Sacdalan, Lishomwa C. Ndhlovu, Bonnie M. Slike, Shelly J. Krebs, Jintanat Anonworanich, Merlin L. Robb, Michael Eller, Joshua Cyktor, Trevor A Crowell, Sandhya Vasan, Frank Kirchhoff
| Nature Verified
Abstract Eliminating latent HIV-1 is a major goal of AIDS research but host factors determining the size of these reservoirs are poorly understood. Here, we investigate the role of host gene expression on HIV-1 reservoir size during suppressive antiretroviral therapy (ART). Peripheral blood cells of fourteen males initiating ART during acute infection and demonstrating effective viral suppression but varying magnitudes of total HIV-1 DNA were characterized by single-cell RNA sequencing.
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Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo

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By Pamela Duran, Georg Duda, Kenneth J. Dery, Aviva Geretz
| Science Magazine Verified
Editor’s summary Identifying factors that restrict human immunodeficiency virus (HIV)–1 replication in vivo may inform potential cure strategies for people living with HIV-1. Here, Geretz et al. analyzed transcripts from both the host and virus within the same single cells to identify host transcripts associated with lower HIV-1 RNA.
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