Meta Volcic

Abstract Sensing of viral pathogens by RIG-I-like receptors (RLRs) requires their priming via dephosphorylation mediated by the protein phosphatase 1 regulatory subunit 12 C (R12C), which is activated upon virus-induced actin rearrangements. Here, we show that the HIV-1 accessory protein Nef prevents R12C-mediated RLR priming, thereby suppressing viral sensing.

Abstract Eliminating latent HIV-1 is a major goal of AIDS research but host factors determining the size of these reservoirs are poorly understood. Here, we investigate the role of host gene expression on HIV-1 reservoir size during suppressive antiretroviral therapy (ART). Peripheral blood cells of fourteen males initiating ART during acute infection and demonstrating effective viral suppression but varying magnitudes of total HIV-1 DNA were characterized by single-cell RNA sequencing.

1 INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets cells of the sino-nasal airway epithelium and is primarily transmitted through respiratory droplets.1 Frequently, SARS-CoV-2 replication is limited to the upper respiratory tract and most infections remain asymptomatic or mild.2 In some cases, however, the virus may spread to the lower respiratory tract, as well as to different organs, causing a broad range of severe and sometimes life-threatening symptoms.3...