Ayse Bercin Barlas

Abbreviations Å, Ångström AF, AlphaFold AIFM1, Apoptosis-inducing factor mitochondrial 1 AK2, Adenylate kinase 2 ATP, Adenosine triphosphate CAPRI, Critical Assessment of PRedicted Interactions cryo-EM, Cryo-electron microscopy Cβ, Beta carbon atom DMPFold, DeepMetaPSICOV Fold EIF2B3, Eukaryotic translation initiation factor 2B subunit 3 IDP, Intrinsically disordered protein IL1R1, Interleukin-1 receptor type 1 MD, Molecular dynamics MIA40, Mitochondrial intermembrane space import and...

Abstract DNMT3A and DNMT3B are closely related DNA methyltransferases that catalyze de novo CpG methylation and have distinct preferences for flanking sequences. Despite sharing 91% sequence similarity within their catalytic domains, these paralogs show non-overlapping genomic targeting and divergent biological roles.

Keywords mitochondria ATP synthesis oxidative phosphorylation OXPHOS energy metabolism apoptosis-inducing factor 1 mitochondrial AIFM1 adenylate kinase 2 AK2 cell signaling protein-protein interaction crosslinking mass spectrometry protein structure Introduction ATP is the central energy carrier of the cell, and its production is fundamental to life.1 In aerobic organisms, the majority of ATP is obtained via the mitochondrial inner membrane (IM) oxidative phosphorylation (OXPHOS) machinery,...