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Azam Rashidian on Muck Rack

Azam Rashidian

As seen in: Nature, ACS Publications
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Articles

Molecular dynamics insights into structural and hydration dynamics of LAT1 bound to ligands and JPH203-induced inward-open arrest

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By Katayun Bahrami, Thales Kronenberger, Azam Rashidian, Tuomo Laitinen, Prasanthi Medarametla, Kristiina Huttunen, Jarkko Rautio, Antti Poso
| Nature Verified
Abstract L-type amino acid transporter 1 (LAT1) delivers amino acids and amino acid-mimicking drugs across blood–brain barrier and is a key underexplored target against cancer. We investigated molecular triggers of LAT1 conformational changes upon ligand binding performing molecular dynamics simulations on LAT1-substrates and one inhibitor. We realized LAT1 conformational change occurs via a two-step expansion-contraction of the mid-section and water flow propels substrate translocation.
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Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors

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By Azam Rashidian, Vinicius Gonçalves Maltarollo, Sini Pitkänen, Ulrich Schoppmeier
| ACS Publications
1. Introduction Click to copy section linkSection link copied! Endocrine-disrupting chemicals (EDCs) are structurally diverse, often lipophilic substances capable of bioaccumulation. Examples of such persistent organic pollutants include fungicides, pesticides, plasticizers, and various polyhalogenated organic compounds, which are present in consumer products, the environment, and industrial emissions.
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Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors

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By Azam Rashidian, Sini Pitkänen, Vinicius Gonçalves Maltarollo, Ulrich Schoppmeier
1. Introduction Click to copy section linkSection link copied! Endocrine-disrupting chemicals (EDCs) are structurally diverse, often lipophilic substances capable of bioaccumulation. Examples of such persistent organic pollutants include fungicides, pesticides, plasticizers, and various polyhalogenated organic compounds, which are present in consumer products, the environment, and industrial emissions.
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