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Prasanthi Medarametla on Muck Rack

Prasanthi Medarametla

As seen in: Nature
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Articles

Molecular dynamics insights into structural and hydration dynamics of LAT1 bound to ligands and JPH203-induced inward-open arrest

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By Katayun Bahrami, Thales Kronenberger, Azam Rashidian, Tuomo Laitinen, Prasanthi Medarametla, Kristiina Huttunen, Jarkko Rautio, Antti Poso
| Nature Verified
Abstract L-type amino acid transporter 1 (LAT1) delivers amino acids and amino acid-mimicking drugs across blood–brain barrier and is a key underexplored target against cancer. We investigated molecular triggers of LAT1 conformational changes upon ligand binding performing molecular dynamics simulations on LAT1-substrates and one inhibitor. We realized LAT1 conformational change occurs via a two-step expansion-contraction of the mid-section and water flow propels substrate translocation.
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A Twist of Fate: The Helix–Turn–Helix Motif in Pseudomonas aeruginosa ExsA Can Allosterically Stabilize the Ligand-Binding Domain

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By Jack Greenhalgh, Ina Pöhner, Martin Welch, Prasanthi Medarametla
| dx.doi.org
1. Introduction Click to copy section linkSection link copied! Pseudomonas aeruginosa (PA) is a ubiquitous Gram-negative pathogen associated with human infections. The organism is particularly well-known to cause airway infections in people with cystic fibrosis (CF) and soft tissue infections in immunocompromised individuals. (1) In 2017, the WHO designated P.
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