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Azusa Matsubara on Muck Rack

Azusa Matsubara

As seen in: Nature
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Articles

Non-genotoxic transplantation and in vivo selection through epitope editing

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By Gabriele Casirati, Andrea Cosentino, Jing ZENG, Adele Mucci, Sébastien Levesque, Nola R. Neri, Enrico Drago, Francesco Romano, Varun Katta, Azusa Matsubara, Yichao Li, Mohammed Mahmoud, Christian Brendel, John Manis, Shengdar Tsai, Danilo Pellin, Daniel Bauer, Pietro Genovese, Marta Freschi, Viola Carzaniga, Moisés Chávez-Navarro
| Nature Verified
Abstract The short-term and long-term effects of genotoxic pre-transplant conditioning remain barriers to the broader application of haematopoietic stem/progenitor cell (HSPC) transplantation and gene therapies1,2,3,4.
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Custom CRISPR—Cas9 PAM variants via scalable engineering and machine learning - Nature

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By Ann-Sophie Kroell, Russell T. Walton, Justin Delano, Martin Pacesa, Leillani L. Ha, Yichao Li, Bruno E. Correia, Shengdar Tsai, Luca Pinello, Azusa Matsubara
| Nature Verified
Abstract Engineering and characterizing proteins can be time-consuming and cumbersome, motivating the development of generalist CRISPR-Cas enzymes1–4 to enable diverse genome editing applications. However, such enzymes have caveats such as an increased risk of off-target editing3,5,6. To enable scalable reprogramming of Cas9 enzymes, here we combined high-throughput protein engineering with machine learning (ML) to derive bespoke editors more uniquely suited to specific targets.
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