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Bachisio Ziccheddu on Muck Rack

Bachisio Ziccheddu

As seen in: BioRxiv
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Articles

RHOA Loss of Function Impairs the IFNγ Response and Promotes CD19 Antigen Escape to Drive CAR-T Resistance in Diffuse Large B-cell Lymphoma

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By Bachisio Ziccheddu, Caroline A Coughlin, Yitzhar E Goretsky, Abdessamad A Youssfi
| BioRxiv
Abstract CD19-directed chimeric antigen receptor (CAR)-T cells are breakthrough therapies for aggressive B-cell lymphomas, but less than half of patients achieve durable responses. We previously showed through whole-genome sequencing of tumors from CAR-T-treated patients that deletions of RHOA (3p21.31) are enriched in cases progressing after treatment.
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The biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma

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By Anthony M Cirrincione, Marcella Kaddoura, Alexandra M Poos, Bachisio Ziccheddu
| uke.de
Research ExplorerPublicationsThe biological and clinical impact of deletions before and a... Abstract Bibliographical data
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