Baihao Zhang on Muck Rack

Baihao Zhang

As seen in: Nature, MDPI, Cell Press
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Articles

Purine salvage pathway protects CD8 + T cells from metabolic stress

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By Masaki Tajima, Baihao Zhang, Yuta Matsuoka, Kazuhiro Sonomura, Koshi Imami, Yosuke Isobe, Rae Maeda, Yu-Hsien Lin, Akihiro Shimba, Ryoma Kato, Akiyo Morinibu, Clive Barker, Jun Seita, Yibo Wu, Seiko Narushima, Rei Nakano, Mikako Maruya, Wakana Kobayashi, Hiroyuki Neyama, Ken-ichi Yamada, Makoto Arita, Yuki Sugiura, Sidonia Fagarasan, Sayaka Washizu, Yosuke Ikejiri, Jumana Shaheen
| Nature Verified
Abstract Metabolic stress from a high-fat diet (HFD) impairs antitumor immunity through persistent metabolic rewiring, but its effects and long-term impact on CD8+ T cell metabolism remain unknown. Here, we found that even temporary exposure to a HFD impaired antitumor immunity 10 weeks after reversion to a normal diet.
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Cell-type specific, inducible and acute degradation of targeted protein in mice by two degron systems - Nature Communications

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By Motoi Yamashita, Baihao Zhang, Aneela Nomura, Satoshi Yamanaka, Yoichi Shinkai, Koshi Imami, Jun Seita, Fumiyuki Shirai, Tatsuya Sawasaki, Masato T. Kanemaki, Sidonia Fargarasan
| Nature Verified
Abstract Despite its broad application in in vitro studies, the application of targeted protein degradation (TPD) to animal models faces considerable challenges. Here, we develop inducible and cell-type specific TPD systems in mice using two degron systems: Oryza sativa TIR1F74G (OsTIR1)-auxin-inducible degron 2 (AID2) and human cereblon (hCRBN)-SALL4 degron (S4D). Efficient degradation of Satb1Venus protein by these systems recapitulates phenotypes observed in the Satb1-deficient mice.
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Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling

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By Masato Ogishi, Kim Good-Jacobson, Darawan Rinchai, Baihao Zhang, Jun Wang, Vincent Gies, Geetha Rao, Tina Nguyen, Danielle T. Avery, Taushif Khan, Megan E. Smithmyer, Joseph Mackie, Rui Yang, Andres Arias, Takaki Asano, Koji Kitaoka, Khoren Pon
| Cell Press Verified
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