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Baivabi Bhattacharya on Muck Rack

Baivabi Bhattacharya

As seen in: BioRxiv
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Articles

Oxysterol accumulation in aging cells alters GPCR signalling

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By Suramya Asthana, Anant Verma, Arnab K Nath, Baivabi Bhattacharya
| BioRxiv
Abstract Organismal aging is accompanied by the accumulation of senescent cells in the body, which drives tissue dysfunction. Senescent cells have a distinctive profile, including proliferation arrest, resistance to apoptosis, altered gene expression, and high inflammation. Despite global signalling and metabolic dysregulation during senescence, the underlying reasons for changes in signalling remain unclear.
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