Bao-Dan He on Muck Rack

Bao-Dan He

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Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease

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By Zi-Xin Wang, Faying Chen, Bao-Dan He, Fan-Chen Wang
| Wiley Online Library
1 Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaque deposition and tau neurofibrillary tangles in the brain, leading to cognitive decline, memory loss, and impaired daily functioning.[1, 2] Risk factors for AD include aging, genetic variants, and lifestyle.[3, 4] Additionally, epigenetic modifications, particularly DNA modifications, have been strongly implicated in AD pathogenesis.[5] Among these, 5-methylcytosine...
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