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Faying Chen

As seen in: Wiley Online Library, Cell Metabolism
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Articles

Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease

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By Zi-Xin Wang, Faying Chen, Bao-Dan He, Fan-Chen Wang
| Wiley Online Library Verified
1 Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaque deposition and tau neurofibrillary tangles in the brain, leading to cognitive decline, memory loss, and impaired daily functioning.[1, 2] Risk factors for AD include aging, genetic variants, and lifestyle.[3, 4] Additionally, epigenetic modifications, particularly DNA modifications, have been strongly implicated in AD pathogenesis.[5] Among these, 5-methylcytosine...
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Pathogen-derived glyoxylate inhibits Tet2 DNA dioxygenase to facilitate bacterial persister formation

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By Zhou-Li Cheng, Shuyuan Zhang, Zhenning Wang, Aixia Song, Chao Gao, Jun-Bin Song, Pu Wang, Lei Zhang, Yue Zhou, Wenyan Shan, Chen Zhang, Jinye Zhang, Yiping Sun, Yanhui Xu, Ming Zhong, Liang-Dong Lyu, Guanghua Huang, fei chen, Zixin Wang, Faying Chen, Jianhuang Xue, Jiejun Shi, Yujun Liu, Zihao Lin, Duojiao Wu, Jim Na, Lei-Lei Chen, Kun-Liang Guan, Yue Xiong, Dan Ye
| Cell Metabolism Verified
Keywords Tet2 DNA dioxygenase glyoxylate pathogenic bacterial persister formation Get full text access Log in, subscribe or purchase for full access. References 1. GBD 2021 Antimicrobial Resistance Collaborators Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 Lancet. 2024; 404:1199-1226 2. Hobby, G.L. ∙ Meyer, K. ∙ Chaffee, E. Observations on the mechanism of action of penicillin Proc. Soc. Exp. Biol. Med. 1942; 50:281-285 3. Bigger, J.
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