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Bar Nathansohn on Muck Rack

Bar Nathansohn

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Bone marrow myelopoiesis dysfunction in Alzheimer’s disease limits monocyte homing to the brain and drives disease progression

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By Miguel Angel Abellanas, Leyre Basurco, Maitreyee Purnapatre, Chiara Burgaletto, Giulia Castellani, Sarah Phoebeluc Colaiuta, Sama Murad, Paola Antonello, Mariángeles Kovacs, Yuliya Androsova, Hannah Partney, Rafael Valdés-Mas, Joseph M. Josephides, Maria Espelosin, Mar Cuadrado-Tejedor, Ana Garcia-Osta, Aleksandra Deczkowska, Michal Schwartz, Javier Maria Peralta-Ramos, Angham Ibraheem, Bar Nathansohn, Liora Cahalon, Tomer M. Salame
| Nature Verified
Abstract Bone marrow-derived macrophages were shown to play an important role in coping with Alzheimer’s disease (AD). Boosting their spontaneous recruitment reduces inflammation and disease pathology and slows cognitive decline in mouse models of amyloidosis. However, the factors limiting their spontaneous homing to the diseased brain remain unclear. In this study, we discovered that monocyte development is impaired in mouse models and in patients.
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