Rafael Valdés-Mas

Abou-Donia M.B. El-Masry E.M. Abdel-Rahman A.A. McLendon R.E. Schiffman S.S. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. J. Toxicol. Environ. Health A. 2008; 71: 1415-1429 Ahmad S.Y. Friel J. Mackay D. The effects of non-nutritive artificial sweeteners, aspartame and sucralose, on the gut microbiome in healthy adults: secondary outcomes of a randomized double-blinded crossover clinical trial. Nutrients.

Phase I clinical trial Trial design This study (NCT04737876) was a randomized, single-blinded, placebo-controlled trial to evaluate the safety, tolerability, and feasibility of an orally administered two-phage combination, to deliver at least one of the two phages that remained viable in the GIT and could be measured in the stool. The study was conducted in the Medpace Clinical Pharmacology Unit (Cincinnati, Ohio, United States) after IND (FDA) and IRB approval.

Abstract Antimicrobial resistance poses a substantial threat to human health. The gut microbiome is considered a reservoir for potential spread of resistance genes from commensals to pathogens, termed the gut resistome. The impact of probiotics, commonly consumed by many in health or in conjunction with the administration of antibiotics, on the gut resistome is elusive.