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Barak Toval on Muck Rack

Barak Toval

As seen in: Nature
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Articles

Fc-optimized GITR antibody enhances a CD4 T cell–dendritic cell crosstalk to promote antitumor immunity

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By Aviya Habshush Menachem, Ella Herzog, Hagar Rotem, Yuval Shapir Itai, Tali Feferman, Moshe Biton, Rony Dahan, Yahel Avraham, Natasha Barth, Tzlil Yair Bar-On, Barak Toval, Jasmine Blanga
| Nature Verified
Abstract Targeting the stimulatory immune checkpoint glucocorticoid-induced TNFR-related protein (GITR) using agonistic monoclonal antibodies (mAbs) is a promising strategy for cancer immunotherapy that activates effector T cells and eliminates regulatory T cells. The antitumor activity of anti-GITR mAbs depends on the engagement of the fragment crystallizable (Fc) domain to their receptors (FcγRs); however, this has not been comprehensively investigated in human anti-GITR mAbs.
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