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Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion
1 Introduction Normothermic machine perfusion (NMP) is a near-physiological preservation technique during which a warm (37°C) perfusion solution is circulated through a donor kidney. This allows cellular metabolism to resume and could permit organ viability assessment prior to transplantation [1].
The association between hemoglobin levels and renal function parameters during normothermic machine perfusion: A retrospective cohort study using porcine kidneys
1 INTRODUCTION Due to the shortage of suitable donor kidneys,1 the use of donation after circulatory death (DCD) and expanded criteria donor kidneys has surged over the last decades.2, 3 These kidneys are generally of inferior quality, as a result of ischemic injury, aging-induced fibrosis, and the adverse effect of the donor's comorbidities.
Furosemide attenuates tubulointerstitial injury and allows functional testing of porcine kidneys during normothermic machine perfusion
1 INTRODUCTION Normothermic (35–37°C) machine perfusion (NMP) has emerged as a promising platform for assessing renal suitability for transplantation.1-3 To increase the diagnostic potential of NMP, biomarkers and functional tests are needed that can provide adequate information about the quality of the kidney during perfusion.
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