Tim L. Hamelink on Muck Rack

Tim L. Hamelink

As seen in: Nature, Wiley Online Library
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Articles

Systematic production of human kidney organoids for transplantation in porcine kidneys during ex vivo machine perfusion - Nature Biomedical Engineering Original

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By Asier Ullate-Agote, Carlos Aranda, Roger Oria, Daniel Lozano-Ojalvo, Tim L. Hamelink, Federico Gonzalez, Aleix Gavaldà-Navarro, Felipe Prosper, Juan R. Rodríguez-Madoz
| Nature Verified
Abstract Organoids derived from human pluripotent stem (hPS) cells hold promise for therapeutic purposes. However, technological advances to overcome their massive production while ensuring differentiation fidelity are still lacking. Here we report a procedure sustaining the derivation of kidney organoids from hPS cells (hPSC-kidney organoids) using a scalable, reproducible and affordable approach that allows hPSC-kidney organoid differentiation into different renal cell types.
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Furosemide attenuates tubulointerstitial injury and allows functional testing of porcine kidneys during normothermic machine perfusion

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By Veerle A. Lantinga, Cyril Moers, Baran Ogurlu, Tim L. Hamelink
| Wiley Online Library Verified
1 INTRODUCTION Normothermic (35–37°C) machine perfusion (NMP) has emerged as a promising platform for assessing renal suitability for transplantation.1-3 To increase the diagnostic potential of NMP, biomarkers and functional tests are needed that can provide adequate information about the quality of the kidney during perfusion.
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