Barbara A. Cohn
Berkeley
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Grandmaternal perinatal serum polychlorinated biphenyls and prevalence of obesity in adult daughters and granddaughters
What is already known? Noncoplanar polychlorinated biphenyl (PCB) 138, PCB 153, and PCB 180 independently increase lipids stored in adipocytes through distinct mechanisms, and their enzyme induction profiles, nuclear receptor activation, and signaling pathways are congener-specific. Fetal life is a window of susceptibility to environmental obesogens, with consequences for obesity over the life course. What does this study add?
387. Prenatal Maternal Inflammation is Associated With Offspring Sensory Gating in Late Midlife
Although sensory gating (SG; ability to filter irrelevant input) naturally declines with age, accelerated SG deficits are a transdiagnostic risk factor for psychopathology. Animal studies suggest these deficits originate in-utero, with prenatal maternal inflammation (PNMI) increasing the risk of neurodevelopmental disorders, particularly in females.
"In Utero Exposure to 17α-Hydroxyprogesterone Caproate and Risk of Canc" by Caitlin C Murphy, Piera M Cirillo et al.
BACKGROUND: 17α-hydroxyprogesterone caproate is a synthetic progestogen initially approved in the 1950s to treat gynecologic and obstetrical conditions. Despite continued concerns about safety and short-term efficacy regarding the use of 17α-hydroxyprogesterone caproate for the prevention of preterm birth in pregnant women, little is known about the long-term effects of 17α-hydroxyprogesterone caproate on the health of the offsprings.
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