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Biomarkers of cancer angioprevention for clinical studies
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The TGF-βR1 inhibitor galunisertib re-shapes the PDAC-TME by limiting decidual-like natural killer cells polarization
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Abstract Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality worldwide. Natural Killer (NKs) cells are pivotal for tumor surveillance but are dysfunctional in PDAC. We evaluated whether pharmacological blockade of TGF-β1/TGF-βR1 axis in PDAC cells and cancer-associated fibroblasts (CAFs) could modulate NK polarization via soluble factors.
By Martina Cucchiara, Maria Teresa Palano, Cristian Rubuano, Gianluca De Antoni, Matteo Gallazzi, Daniele Mercatelli, Marta Tagliabue, Maria Gemelli, Pier Francesco Ferrucci, Gennaro Nappo, Silvia Uccella, Alessandro Zerbi, Patrizia Borsotti, Nicolò Baranzini, Annalisa Grimaldi, Lorenzo Mortara, Francesco Acquati, Paola Muti, Bárbara Bassani, Antonino Bruno, Adelaide Pessi, Gianpiero Catalano, Riccardo Ricotta, Giulia Garattini, Federica Di Leva, Dorina Belotti, Andrea Resovi
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Nature
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MiR-223-3p in Cancer Development and Cancer Drug Resistance: Same Coin, Different Faces
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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