Barbara Burtness
As seen in:
Nature,
Wiley Online Library,
MDPI,
JAMA Oncology,
The Lancet,
Healio,
HemOnc Today,
Newswise,
NewsBreak,
Journal of Clinical Oncology
and
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Choosing Between Approved Frontline Metastatic Pancreatic Cancer Regimens
With 3 regimens now approved for the frontline treatment of metastatic pancreatic cancer, oncologists face an increasingly complex decision about which combination to use first, and how that choice affects a patient's options down the line. NALIRIFOX (liposomal irinotecan [Onivyde], oxaliplatin, 5-fluorouracil [5-FU], and leucovorin) was evaluated against gemcitabine plus nab-paclitaxel (Abraxane) in the phase 3 NAPOLI-3 trial (NCT04083235).
Safusidenib Earns FDA Fast Track Designation for IDH1-Mutant Glioma
The FDA has granted fast track designation to safusidenib, an investigational, oral, brain-penetrant selective inhibitor of mutant IDH1, for the treatment of patients with IDH1-mutant glioma, according to a news release from the company.1 The designation is supported by favorable data from safusidenib in this patient population.
Belzutifan Combo Improves Disease Control Vs Cabozantinib in Advanced RCC
Results from the phase 3 LITESPARK-011 trial (NCT04586231) showed that belzutifan (Welireg) plus lenvatinib (Lenvima) significantly improved disease control compared with cabozantinib (Cabometyx) in patients with previously treated advanced clear cell renal cell carcinoma (ccRCC), according to a news release from the Vall d'Hebron Institute of Oncology (VHIO).¹ What did the phase 3 LITESPARK-011 trial show?
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