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A pilot study of immunotherapy in dogs with atopic dermatitis using a mannan‐Dermatophagoides farinae allergoid targeting dendritic cells
Polymerized allergoids coupled to nonoxidized mannan (PM‐allergoids) are novel allergen preparations used for immunotherapy. To evaluate PM‐allergoids as an alternative immunotherapy for dogs with canine atopic dermatitis (cAD) associated with serological responses to Dermatophagoides farinae allergens. Sixteen dogs with history and clinical signs of cAD; positive on serum allergen specific IgE testing to D. farinae.
A pilot study of immunotherapy in dogs with atopic dermatitis using a mannan‐Dermatophagoides farinae allergoid targeting dendritic cells
Polymerized allergoids coupled to nonoxidized mannan (PM‐allergoids) are novel allergen preparations used for immunotherapy. To evaluate PM‐allergoids as an alternative immunotherapy for dogs with canine atopic dermatitis (cAD) associated with serological responses to Dermatophagoides farinae allergens. Sixteen dogs with history and clinical signs of cAD; positive on serum allergen specific IgE testing to D. farinae.
Oral myeloid cells uptake allergoids coupled to mannan driving Th1/Treg responses upon sublingual delivery in mice
Polymerized allergoids coupled to nonoxidized mannan (PM-allergoids) may represent novel vaccines targeting dendritic cells (DCs). PM-allergoids are better captured by DCs than native allergens and favor Th1/Treg cell responses upon subcutaneous injection. Herein we have studied in mice the in vivo immunogenicity of PM-allergoids administered sublingually in comparison to native allergens. Three immunization protocols (4-8 weeks long) were used in Balb/c mice.
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