Barbara Chiavarina

Main text (Cell Reports 30, 1400–1416; February 4, 2020) As published, Panels 5D (AKT) and 5I (β-actin KRAS G12V) contain unintended duplication. This error was determined to have occurred during the process of figure preparation, when scans were inadvertently interchanged. The authors have reviewed the original data and provided a corrected Figure 5, with accurate blot scan images, which can be seen below.

Introduction Nuclear receptors (NRs) are a family of transcription factors involved in the gene regulation of key physiological processes. Among NRs, the peroxisome proliferator-activated receptors (PPARs) are the target of fatty acids, eicosanoids (prostaglandins, leukotrienes), and vitamin B3 notably, and they are involved in the regulation of glucose, lipid, and cholesterol metabolism.

Abstract Previously, we proposed a new model for understanding the "Warburg effect" in tumor metabolism. In this scheme, cancer-associated fibroblasts undergo aerobic glycolysis and the resulting energy-rich metabolites are then transferred to epithelial cancer cells, where they enter the TCA cycle, resulting in high ATP production via oxidative phosphorylation.