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Barbara Choromańska

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Articles

Enhanced Proteolytic and Glycooxidative Activity in Visceral Adipose Tissue in Obesity: A Tissue-Level Comparative Study

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By Konrad Wisniewski, Barbara Choromańska, Mateusz Maciejczyk
| Preprints.org
You are already at the latest version Background: Adipose tissue expansion in obesity is accompanied by extracellular matrix (ECM) remodelling, regulated by matrix metalloproteinases (MMPs). Visceral adipose tissue (VAT) is metabolically more active than subcutaneous adipose tissue (SAT). However, depot-specific differences in proteolytic activity and protein glycooxi-dation remain incompletely characterized.
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Obesity as a Disease of Visceral Adipose Tissue: MMP Activation and AGE Accumulation as Key Mechanisms of Metabolic Complications

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By Konrad Wisniewski, Barbara Choromańska, Mateusz Maciejczyk, Alan Tkaczuk
| Preprints.org
Submitted: 01 December 2025 You are already at the latest version obesity ; visceral adipose tissue ; subcutaneous adipose tissue ; matrix metalloproteinases ; extracellular matrix remodeling ; advanced glycation end-products ; glycooxidation ; metabolic complications ; adipose tissue inflammation ; tissue remodeling This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint...
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Modulating Matrix Metalloproteinase Activity in Obesity: Comparative Effects of Bariatric Surgery and GLP-1/GIP-Based Pharmacotherapy

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By Mateusz Maciejczyk, Barbara Choromańska, Jacek Dadan
| Preprints.org
Submitted: 12 September 2025 Posted: 15 September 2025 You are already at the latest version Obesity is a multifactorial metabolic disease characterized by chronic low-grade inflammation, extracellular matrix (ECM) dysfunction, and systemic metabolic dysregulation. Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, are key regulators of ECM remodeling and inflammation in obesity.
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