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Barbara Clough on Muck Rack

Barbara Clough

As seen in: BioRxiv, Cell Reports, Microbiology Research
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Articles

Strain-dependent contribution of the AcrAB-TolC efflux pump to Klebsiella pneumoniae physiology

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By Barbara Clough, Charlotte Emmerson, Kirandeep Bhogal, Archie Organ
| Microbiology Research
Article metrics loading... /content/journal/micro/10.1099/mic.0.001647 Metrics Download as PowerPoint /deliver/fulltext/micro/171/12/mic001647.html?itemId=/content/journal/micro/10.1099/mic.0.001647&mimeType=html&fmt=ahah References Temkin E, Fallach N, Almagor J, Gladstone BP, Tacconelli E et al. Estimating the number of infections caused by antibiotic-resistant Escherichia coli and Klebsiella pneumoniae in 2014: a modelling study.
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p97/VCP targets Toxoplasma gondii vacuoles for parasite restriction in interferon-stimulated human cells

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By Barbara Clough, Daniel Fisch, Vesela Encheva, Todd H Mize
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

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By Byrne G.I, Marie-Charlotte Domart, Daniel Fisch, Barbara Clough
| Cell Reports Verified
Highlights • Development of two microscopy assays for microbe/microbe-containing vacuole lysis • Human GBP1 is essential for the lysis of Toxoplasma gondii vacuoles and parasites • Caspase-4 recruitment, but not cytosolic escape of Salmonella, is GBP1 dependent • Caspase-1 cleaves and inactivates GBP1 and suppresses caspase-4-driven pyroptosis Summary Interferon-inducible guanylate-binding proteins (GBPs) promote cell-intrinsic defense through host cell death.
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