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Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus - Nature Human Behaviour
Author notes These authors contributed equally: Iain Mathieson, Felix R. Day, Nicola Barban, Felix C. Tropf, David M. Brazel, Melinda C. Mills, John R. B. Perry. Authors and Affiliations Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Iain Mathieson & Bárbara D. Bitarello MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK Felix R. Day, Eugene J.
Polygenic Scores for Height in Admixed Populations
G3: Genes, Genomes, Genetics November 1, 2020 vol. 10 no. 11 4027-4036; https://doi.org/10.1534/g3.120.401658 Open Access Abstract Polygenic risk scores (PRS) use the results of genome-wide association studies (GWAS) to predict quantitative phenotypes or disease risk at an individual level, and provide a potential route to the use of genetic data in personalized medical care. However, a major barrier to the use of PRS is that the majority of GWAS come from cohorts of European ancestry.
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