Hamdi Mbarek

Emerging computational approaches that measure the functional impact of HLA variation offer an opportunity to represent aspects of antigen-presentation diversity as quantitative genomic measures rather than as solely as categorical genetic features. The era of population genomics now provides the scale needed to benchmark these approaches and determine whether such measures can serve as proxies for immune diversity.

Abstract Obesity is a major public health challenge. Glucagon-like peptide-1 receptor agonists (GLP1-RA) and bariatric surgery (BS) are effective weight loss interventions; however, the genetic factors influencing treatment response remain largely unexplored. Moreover, most previous studies have focused on race and ethnicity rather than genetic ancestry.

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