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Immunophenotypic skewing of B cells toward IgD⁻CD27⁻IgG⁺ subtype and metabolic attenuation in colorectal cancer - Scientific Reports
Abstract Colorectal cancer (CRC) is the third most prevalent cancer and understanding its tumor microenvironment (TME) is crucial for the development of innovative therapies. Despite the presence of B cells in CRC infiltrate, their clinical significance is poorly understood. In this study, we observed an enrichment of double-negative (DN) B cells, a subset lacking surface IgD and CD27, in CRC biopsies.
Investigating the hypoglycaemic potential of processed apple and acarbose combination in vitro, ex vivo, and in vivo: the role of quercetin-3-glucoside in steering α-glucosidase inhibition
Investigating the hypoglycaemic potential of processed apple and acarbose combination in vitro, ex vivo, and in vivo: the role of quercetin-3-glucoside in steering α-glucosidase inhibition This study investigated the interaction between apple juice (AJ) and acarbose (A) in modulating glycemic responses, with the aim of validating in vivo results previously observed in vitro.
Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination
Barbara Frossi‡1, Giulia Antoniali§1, Kefei Yu¶, Nahid Akhtar‖, Mark H. Kaplan‖, Mark R. Kelley‖, Gianluca Tell§2 and Carlo E. M. Pucillo‡3 From the ‡Laboratory of Immunology, Department of Medicine, University of Udine, 33100 Udine, Italy, the §Laboratory of Molecular Biology and DNA Repair, Department of Medicine, University of Udine, 33100 Udine, Italy, the ¶Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, and the ‖Herman B.
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