Barbara G. Silverman

Introduction Gaucher disease (GD) is one of the two most common lysosomal storage disorders (LSDs) and the first to benefit from safe and effective therapy. The introduction of the placental-derived, macrophage-targeted enzyme replacement therapy (ERT) in 19911 marked a turning point, not only for GD but also for other LSDs and the broader rare disease field.

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Abstract Objective To evaluate trends in the incidence and survival of gynecologic carcinosarcoma over the last 35 years and to explore ethnic disparities. Study design Using the Israeli National Cancer Registry database, all cases of gynecologic carcinosarcoma were included (1980-2014). Age at diagnosis, patient’s ethnicity and anatomical site were extracted. Age-standardized incidence rates (ASRs) were calculated for 3 time periods (1980-1994, 1995-2004 and 2005-2014).