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Barbara Ghiglione

As seen in: American Society for Microbiology (ASM)
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Articles

Outbreak of NDM-5-Producing Proteus mirabilis During the COVID-19 Pandemic in an Argentine Hospital

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By Barbara Ghiglione, Ana Rodriguez, Ana Paula Rodríguez, María Sol Haim, Laura Friedman
| Preprints.org
You are already at the latest version During the COVID-19 pandemic, the emergence of multidrug-resistant (MDR) pathogens, driven by heightened antibiotic usage and device-associated infections, has posed significant challenges to healthcare. This study reports an outbreak of Proteus mirabilis producing NDM-5 and CTX-M-15 β-lactamases in a hospital in Buenos Aires, Argentina, from October 2020 to April 2021. To our knowledge, this represents the first documented outbreak of NDM-5-producing P.
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Structural and Biochemical Characterization of the Novel CTX-M-151 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam

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By Barbara Ghiglione, Robert Bonomo, Gabriel O. Gutkind, Pablo Power
| American Society for Microbiology (ASM)
Mechanisms of Resistance Barbara Ghiglione, María Margarita Rodríguez, Florencia Brunetti, Krisztina M. Papp-Wallace, Ayumi Yoshizumi, Yoshikazu Ishii, Robert A. Bonomo, Gabriel Gutkind, Sebastián Klinke, Pablo Power DOI: 10.1128/AAC.01757-20 ABSTRACT The diazabicyclooctane (DBO) inhibitor avibactam (AVI) reversibly inactivates most serine β-lactamases, including the CTX-M β-lactamases.
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Proposing Kluyvera georgiana as the Origin of the Plasmid-Mediated Resistance Gene fosA4

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By Maria Rodriguez, Cátedra de Microbiología, Barbara Ghiglione
| American Society for Microbiology (ASM)
A putative fosA gene in Kluyvera georgiana 14751 showed 99% nucleotide identity with plasmid-encoded fosA4. Due to a single-nucleotide insertion translating to a truncated protein, K. georgiana 14751 fosA does not confer fosfomycin resistance. However, analysis of another genome deposit (Kluyvera ascorbata WCH1410) that could be recategorized as K. georgiana after phylogenetic analysis revealed a fosA gene 100% identical to the plasmid-borne fosA4 gene.
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