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Barbara I. Streibl on Muck Rack

Barbara I. Streibl

As seen in: Cell Press
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Articles

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids

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By Birgitta E. Michels, Mohammed H. Mosa, Barbara I. Streibl, Tianzuo Zhan
| Cell Press Verified
Highlights • An optimized protocol for pooled CRISPR-Cas9 library screening in human colon organoids • Organoid xenografts enable unbiased identification of in vivo tumor suppressors • gRNA functionality in organoids is less predictable compared to 2D cancer cell lines • Clonal tracing with a UMI library allows adjustment for clonal drift during selection Summary Colorectal cancer (CRC) is characterized by prominent genetic and phenotypic heterogeneity between patients.
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