Barbara Imbrosci

Introduction The hippocampus is critical for systems memory consolidation, and hippocampal ripples – often in conjunction with local field potential (LFP) sharp waves (sharp wave ripple complexes, SPW-Rs) – are thought to be a mechanism for the transfer of memories from the hippocampus to the neocortex (Buzsáki, 2015; Jadhav et al., 2016). During SPW-Rs, hippocampal ensembles are reactivated (Kudrimoti et al., 1999; Lee & Wilson, 2002; Nádasdy et al., 1999; Wilson & McNaughton, 1994).

Research ArticleResearch Article: Methods/New Tools, Novel Tools and Methods Barbara Imbrosci, Dietmar Schmitz and Marta Orlando eNeuro 4 January 2022, 9 (1) ENEURO.0400-20.2021; DOI: https://doi.org/10.1523/ENEURO.0400-20.2021 Abstract Information transfer and integration in the brain occurs at chemical synapses and is mediated by the fusion of synaptic vesicles filled with neurotransmitter.

Highlights • A fraction of sharp wave-ripples does not rely on CA2/3 generation • The subiculum can work as independent generator for sharp wave-ripples • These events can propagate back from the subiculum into CA1 and CA3 Summary Sharp wave-ripples (SWRs) represent synchronous discharges of hippocampal neurons and are believed to play a major role in memory consolidation. A large body of evidence suggests that SWRs are exclusively generated in the CA3-CA2 network.