Barbara Kroczynska

Ewa M. Kosciuczuk‡,§,¶1, Swarna Mehrotra‡,§1, Diana Saleiro‡,§2, Barbara Kroczynska‡,‖, Beata Majchrzak-Kita**, Pawel Lisowski‡‡,§§,¶¶3, Caroline Driehaus‡, Anna Rogalska‡, Acara Turner‡, Thomas Lienhoop‡, David Gius‡,‖, Eleanor N. Fish**4, Athanassios Vassilopoulos‡,‖5 and Leonidas C. Platanias‡,§,¶6 From the ‡Robert H.

Author contributions: E.M.K. formal analysis; E.M.K., S.M., D.S., B.K., B.M.-K., D.G., E.N.F., A.V., and L.C.P. validation; E.M.K., S.M., C.D., A.R., A.T., T.L., and L.C.P. investigation; E.M.K., S.M., D.S., B.K., B.M.-K., P.L., C.D., A.R., A.T., T.L., D.G., E.N.F., A.V., and L.C.P. methodology; E.M.K., E.N.F., and L.C.P. writing-original draft; E.M.K., S.M., and L.C.P. project administration; E.M.K., D.S., E.N.F., A.V., and L.C.P. writing-review and editing; P.L. visualization; L.C.P....

The precise signaling mechanisms by which type II IFN receptors control expression of unique genes to induce biological responses remain to be established. We provide evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for IFN?-induced phosphorylation and activation of AKT and that such activation mediates downstream regulation of mTORC1 and its effectors.