Barbara L Kee
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Genomic and Transcriptional Mechanisms Governing Innate-like T Lymphocyte Development
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It’s a Phase That EBF1 Is Going Through
Lineage-specific programming of chromatin requires transcription factors to bind inaccessible chromatin. Wang et al. find that “pioneering” by the transcription factor EBF1 involves a prion-like domain that enables recruitment of chromatin remodelers and formation of phase-separated condensates. Partitioning of EBF1-bound sites into condensates may coordinate expression of B lineage genes.
The transcription factor BCL-6 controls early development of innate-like T cells
Abstract Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. How this program is initiated is currently unclear. Here, we show that the transcription factor BCL-6 was transiently expressed in iNKT cells upon exit from positive selection and was required for their proper development beyond stage 0.
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