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Plasma Amyloid-β 1-40 and Postoperative Delirium After Cardiac Surgery
Plasma Amyloid-β 1-40 and Postoperative Delirium After Cardiac Surgery Supplement 1. eTable 1. Multiple linear regression with MoCA as dependent variable without influential observation (N = 477) eTable 2. Simple logistic regressions for POD eTable 3. Area under the curve and prognostic accuracy at optimal cutoff values for POD state eTable 4. Multiple logistic regressions for POD – Model 5-7 eTable 5.
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice - Nature Neuroscience
Abstract Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer’s disease (AD). However, transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally abundant in oligodendrocytes (OLs). By cell-type-specific deletion of Bace1 in a humanized knock-in AD model, APPNLGF, we demonstrate that OLs and neurons contribute to Aβ plaque burden. For rapid plaque seeding, excitatory projection neurons must provide a threshold level of Aβ.
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