Barbara Morgado

Abstract The role of physical fitness in cognitive reserve and brain maintenance remains unclear. We investigated the associations of muscular and aerobic fitness (VO2max) with markers of brain health and cognition in 353 cognitively unimpaired older adults (mean age = 72.77 ±  7.95 years; 177 females). Muscular fitness comprised handgrip strength, appendicular skeletal muscle mass, and Timed-Up-and-Go performance.

Plasma Amyloid-β 1-40 and Postoperative Delirium After Cardiac Surgery Supplement 1. eTable 1. Multiple linear regression with MoCA as dependent variable without influential observation (N = 477) eTable 2. Simple logistic regressions for POD eTable 3. Area under the curve and prognostic accuracy at optimal cutoff values for POD state eTable 4. Multiple logistic regressions for POD – Model 5-7 eTable 5.

Abstract Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer’s disease (AD). However, transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally abundant in oligodendrocytes (OLs). By cell-type-specific deletion of Bace1 in a humanized knock-in AD model, APPNLGF, we demonstrate that OLs and neurons contribute to Aβ plaque burden. For rapid plaque seeding, excitatory projection neurons must provide a threshold level of Aβ.