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Barbara S. Paugh on Muck Rack

Barbara S. Paugh

As seen in: Cell Press
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Articles

Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

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By Jon Larson, Lawryn H. Kasper, Barbara S. Paugh, Hongjian Jin
| Cell Press Verified
Highlights • H3.3 K27M mutation enhances neural stem cell self-renewal • Neonatal PDGFRα activation and Trp53 loss induces supratentorial and brainstem glioma • H3.3 K27M preferentially accelerates hindbrain tumorigenesis • H3.3 K27M drives bivalent gene activation associated with neurodevelopment in DIPG Summary Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53.
Open in Who Shared Issue with article?

Cell Press: Cell Press

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By Jon Larson, Gang Wu, Timothy Shaw, Raymond Xu, Xiaoyan Zhu, Helen Russell, Jennifer Peters, David Finkelstein, Beisi Xu, Lawryn H. Kasper, Barbara S. Paugh, Hongjian Jin, Chang-Hyuk Kwon, André B. Silveira, Chunxu Qu, Junyuan Zhang
| Cell Press Verified
Open in Who Shared Issue with article?
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