Bárbara Santos
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Clock gene signature predicts insomnia and links to sleep/circadian parameters
Abstract Chronic Insomnia is a prevalent sleep disorder that remains difficult to diagnose due to subjective symptoms and heterogeneous presentations. The most severe form, insomnia with short sleep duration (ISSD), is defined by a total sleep time of less than six hours on polysomnography. However, objective assessments are rarely recommended in diagnostic guidelines, highlighting the need for alternative biomarkers.
International multisite implementation of distributed cell-free protein biomanufacturing to advance health and research equity
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Limitations in global access to research and health care capacity undermine equity, sustainability, and resilience, particularly in resource-limited settings.
By Xiao Yu, Fan Xia, Bolan Gan, Quinn Matthews, Séverine Marianne Cazaux, Justin R. J. Vigar, Bárbara Santos, Deyse Carvalho, Lauren Cranmer, David Duplat, Serena Singh, Mohammad Simchi, Paula Benitez-Bolivar, Kaiyue Wu, Tanvi Kale, Jennifer Doucet, Anibal Arce, Cielo León, Jessica Nguyen, Anson Ho, Renata P. G. Mendes, Ana L. L. Divarzak, Kristof Bozovicar, Valentina Ferrando, Suelen C. de Lima
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Science Magazine
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“Intranasal vaccination with recombinant human adenovirus encoding the trans -sialidase gene protects mice from lethal subcutaneous and oral Trypanosoma cruzi trypomastigote challenges”
The majority of new cases of Chagas’ disease, caused by Trypanosoma cruzi, have been associated with oral infection. Thus, it is reasonable that any vaccine formulation developed should elicit systemic and mucosal immunity. Antigen-specific T-, B-cell, antibody-secreting cell, IgG, IgA, cytokine and parasite DNA were assessed in Balb/c mice immunized with a recombinant adenovirus replication-deficient vector encoding the parasitic trans-sialidase (rAdTS) and challenged with T.
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