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Barbara Scappini on Muck Rack

Barbara Scappini

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Genomic structural variations contribute to inform prognosis in patients with cytogenetically normal acute myeloid leukemia - Blood Cancer Journal

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By Niccolò Bartalucci, Francesco Mannelli, Danilo Tarantino, Alessio Enderti, Simone Romagnoli, Daniele Colazzo, Barbara Scappini, Matteo Piccini, Leonardo Signori, Tiziana Ottone, Alfonso Piciocchi, Margherita Vannucchi, Maria Chiara Siciliano, Silvia Orsi, Paola Fazi, Raffaella Santi, Marco Vignetti, Stefania Bortoluzzi, Alberto Bosi, Adriano Venditti, Alessandro Rambaldi, Maria Teresa Voso, Paola Guglielmelli, Alessandro Vannucchi, Giacomo Gianfaldoni, Fiorenza Irushani, Silvia Salmoiraghi, Roberto Boccacci, Alessia Civini
| Nature Verified
Abstract Cytogenetic and genomic profiling of acute myeloid leukemia (AML) guides personalized treatment according to ELN2022 recommendations. However, marked outcome variability persists among cytogenetically normal (CN-) patients, representing an unmet clinical need. We used long-read whole-genome sequencing to interrogate the prognostic significance of structural variations (SVs) in a prospective cohort of 162 intensively treated CN-AML patients.
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